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Parasite enzymes as potential targets for antiparasitic chemotherapy Ching Chung Wang pp 1 - 9; DOI: 10.1021/jm00367a001 |
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(E)-2-(3,4-dimethoxyphenyl)-3-fluoroallylamine: a selective, enzyme-activated inhibitor of type B monoamine oxidase Philippe Bey, John Fozard, Jean Michel Lacoste, Ian A. McDonald, Monique Zreika, and Michael G. Palfreyman pp 9 - 10; DOI: 10.1021/jm00367a002 |
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Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate Sudhir Ajmera, Ashok R. Bapat, Kathleen Danenberg, and Peter V. Danenberg pp 11 - 14; DOI: 10.1021/jm00367a003 |
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Structure-activity relationship study of the inhibition of adrenal cortical 11.beta.-hydroxylase by new metyrapone analogs Sheryl J. Hays, Michael C. Tobes, David L. Gildersleeve, Donald M. Wieland, and William H. Beierwaltes pp 15 - 19; DOI: 10.1021/jm00367a004 |
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Stereochemical considerations and the antiinflammatory activity of 6-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols and related derivatives Shing Chun Wong, Sandra Sasso, Howard Jones, and James J. Kaminski pp 20 - 27; DOI: 10.1021/jm00367a005 |
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Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3',4'-dihydroxynomifensine Penelope A. Dandridge, Carl Kaiser, Martin Brenner, Dimitri Gaitanopoulos, Larry D. Davis, R. Lee Webb, James J. Foley, and Henry M. Sarau pp 28 - 35; DOI: 10.1021/jm00367a006 |
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Trypanocidal 1,3-arylene diketone bis(guanylhydrazones). Structure-activity relationships among substituted and heterocyclic analogs Peter Ulrich and Anthony Cerami pp 35 - 40; DOI: 10.1021/jm00367a007 |
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Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines Richard A. Glennon, John M. Jacyno, R. Young, J. D. McKenney, and David Nelson pp 41 - 45; DOI: 10.1021/jm00367a008 |
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8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists Lars Erik Arvidsson, Uli Hacksell, Anette Johansson, J. Lars G. Nilsson, Per Lindberg, Domingo Sanchez, Haakan Wikstroem, Kjell Svensson, Stephan Hjorth, and Arvid Carlsson pp 45 - 51; DOI: 10.1021/jm00367a009 |
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Palladium(II)-catalyzed olefin-coupling reactions of kainic acid: effects of substitution on the isopropenyl group on receptor binding Gregory A. Conway, Joon Sup Park, Linda Maggiora, Mathias P. Mertes, Noemi Galton, and Elias K. Michaelis pp 52 - 56; DOI: 10.1021/jm00367a010 |
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Effect of tellurium position on the myocardial uptake of radioiodinated 18-iodotellura-17-octadecenoic acid analogs F. F. Knapp, P. C. Srivastava, A. P. Callahan, E. B. Cunningham, G. W. Kabalka, and K. A. R. Sastry pp 57 - 63; DOI: 10.1021/jm00367a011 |
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Electronic structures of cephalosporins and penicillins. 15. Inductive effect of the 3-position side chain in cephalosporins Donald B. Boyd pp 63 - 66; DOI: 10.1021/jm00367a012 |
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A cannabinoid derived prototypical analgesic Lawrence S. Melvin, M. Ross Johnson, Charles A. Harbert, George M. Milne, and Albert Weissman pp 67 - 71; DOI: 10.1021/jm00367a013 |
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Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles. Isomeric 4-pyridyl and 4-substituted-phenyl derivatives I. Lantos, P. E. Bender, K. A. Razgaitis, B. M. Sutton, M. J. DiMartino, D. E. Griswold, and D. T. Walz pp 72 - 75; DOI: 10.1021/jm00367a014 |
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Structure-activity relationships of phenytoin-like anticonvulsant drugs Jacques H. Poupaert, Daniel Vandervorst, Pierre Guiot, Mohamed M. M. Moustafa, and Pierre Dumont pp 76 - 78; DOI: 10.1021/jm00367a015 |
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Receptor binding sites of hypoglycemic sulfonylureas and related [(acylamino)alkyl]benzoic acids George R. Brown and Alan J. Foubister pp 79 - 81; DOI: 10.1021/jm00367a016 |
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Novel tetracyclic spiropiperidines. 4. Synthesis and pharmacological evaluation of spiro- and 6,7-dihydrospiro[benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine-2H(1H),4'-piperidine]s Edward J. Glamkowski, James M. Fortunato, Helen H. Ong, Richard C. Allen, Jeffrey C. Wilker, and Harry M. Geyer pp 81 - 83; DOI: 10.1021/jm00367a017 |
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2-Acetylpyridine thiosemicarbazones. 8. Derivatives of 1-acetylisoquinoline as potential antimalarial agents Daniel L. Klayman, John P. Scovill, Joseph Bruce, and Joseph F. Bartosevich pp 84 - 87; DOI: 10.1021/jm00367a018 |
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2-Acetylpyridine thiosemicarbazones. 9. Derivatives of 2-acetylpyridine 1-oxide as potential antimalarial agents John P. Scovill, Daniel L. Klayman, Chris Lambros, George E. Childs, and John D. Notsch pp 87 - 91; DOI: 10.1021/jm00367a019 |
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Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)uracils Kyoichi A. Watanabe, Tsann Long Su, Uri Reichman, Nancy Greenberg, Carlos Lopez, and Jack J. Fox pp 91 - 94; DOI: 10.1021/jm00367a020 |
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Synthesis and evaluation of radioiodinated (E)-18-iodo-17-octadecenoic acid as a model iodoalkenyl fatty acid for myocardial imaging F. F. Knapp, M. M. Goodman, G. W. Kabalka, and K. A. R. Sastry pp 94 - 97; DOI: 10.1021/jm00367a021 |
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cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor Thomas P. Johnston, George S. McCaleb, William C. Rose, and John A. Montgomery pp 97 - 99; DOI: 10.1021/jm00367a022 |
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Book Reviews pp 100 - 102; DOI: 10.1021/jm00367a600 |
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Design, synthesis, and testing of potential antisickling agents. 3. Ethacrynic acid Paul E. Kennedy, Franki L. Williams, and Donald J. Abraham pp 103 - 105; DOI: 10.1021/jm00368a001 |
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Design, synthesis, and binding characteristics of an opiate receptor mimetic peptide Willi Kullmann pp 106 - 115; DOI: 10.1021/jm00368a002 |
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Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity Ronald G. Almquist, Cris M. Olsen, Edward T. Uyeno, and Lawrence Toll pp 115 - 120; DOI: 10.1021/jm00368a003 |
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Synthesis of 2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl) benzo heterocycles. A novel series of orally active antiallergic agents John H. Musser, Richard E. Brown, Bernard Loev, Kevin Bailey, Howard Jones, Robert Kahen, Fuchih Huang, Atul Khandwala, Mitchell Leibowitz, and et al. pp 121 - 125; DOI: 10.1021/jm00368a004 |
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Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides Yasushi Honma, Kyoji Hanamoto, Tomiki Hashiyama, Yasuo Sekine, Mikio Takeda, Yasutoshi Ono, and Kei Tsuzurahara pp 125 - 128; DOI: 10.1021/jm00368a005 |
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Crystallography, quantitative structure-activity relationships, (QSAR) and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines Corwin Hansch, Bruce A. Hathaway, Zongru Guo, Cynthia Dias Selassie, Stephen W. Dietrich, Jeffrey M. Blaney, Robert Langridge, Karl W. Volz, and Bernard T. Kaufman pp 129 - 143; DOI: 10.1021/jm00368a006 |
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Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. A quantitative structure-activity relationship analysis Bruce A. Hathaway, Zong Ru Guo, Corwin Hansch, Tavner J. Delcamp, Sandra S. Susten, and James H. Freisheim pp 144 - 149; DOI: 10.1021/jm00368a007 |
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Adrenal medulla imaging agents: a structure-distribution relationship study of radiolabeled aralkylguanidines Donald M. Wieland, Thomas J. Mangner, Muthiah N. Inbasekaran, Lawrence E. Brown, and Jiann Long Wu pp 149 - 155; DOI: 10.1021/jm00368a008 |
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Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(4-iodophenyl)-.alpha.-phenylacetate as potential radiopharmaceuticals W. J. Rzeszotarski, W. C. Eckelman, B. E. Francis, D. A. Simms, R. E. Gibson, E. M. Jagoda, M. P. Grissom, R. R. Eng, J. J. Conklin, and R. C. Reba pp 156 - 160; DOI: 10.1021/jm00368a009 |
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Synthesis of 3-hydroxy-2- and -4-pyridone nucleosides as potential antitumor agents David T. Mao, John S. Driscoll, and Victor E. Marquez pp 160 - 164; DOI: 10.1021/jm00368a010 |
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Design, synthesis, and x-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties Rene Imhof, Emilio Kyburz, and John J. Daly pp 165 - 175; DOI: 10.1021/jm00368a011 |
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Synthesis and characterization of N2-(p-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase .alpha. George E. Wright and Lech W. Dudycz pp 175 - 181; DOI: 10.1021/jm00368a012 |
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Quantitative structure-activity relationships of 6-anilinouracils as inhibitors of Bacillus subtilis DNA polymerase III George E. Wright and Joseph J. Gambino pp 181 - 185; DOI: 10.1021/jm00368a013 |
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Resorcinol congeners of dopamine derived from benzocycloheptene and indan Joseph G. Cannon, Jonathan P. Pease, Richard L. Hamer, Mustafa Ilhan, Ranbir K. Bhatnagar, and John P. Long pp 186 - 189; DOI: 10.1021/jm00368a014 |
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Conformationally restricted congeners of dopamine derived from octahydrobenzo[g]quinoline and octahydrobenzo[f]quinoline Joseph G. Cannon, Richard L. Hamer, Mustafa Ilhan, Ranbir K. Bhatnagar, and John P. Long pp 190 - 195; DOI: 10.1021/jm00368a015 |
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Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, a novel broad-spectrum antitumor agent Malcolm F. G. Stevens, John A. Hickman, Robert Stone, Neil W. Gibson, Ghouse Unissa Baig, Edward Lunt, and Christopher G. Newton pp 196 - 201; DOI: 10.1021/jm00368a016 |
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Synthesis and anticonvulsant activity of some substituted lactams and amides Wayne J. Brouillette and Gary L. Grunewald pp 202 - 206; DOI: 10.1021/jm00368a017 |
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Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties Claire Sablayrolles, Jean Claude Milhavet, Eliane Rechenq, Jean Pierre Chapat, Gerard H. Cros, Maurice Boucard, Jean J. Serrano, and John H. McNeill pp 206 - 212; DOI: 10.1021/jm00368a018 |
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Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds Atsusuke Terada, Shunji Naruto, Kazuyuki Wachi, Shigeru Tanaka, Yoshio Iizuka, and Eiichi Misaka pp 212 - 216; DOI: 10.1021/jm00368a019 |
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Synthesis and antimicrobial activity of clindamycin analogs: pirlimycin, a potent antibacterial agent Robert D. Birkenmeyer, Stephen J. Kroll, Charles Lewis, Kurt F. Stern, and Gary E. Zurenko pp 216 - 223; DOI: 10.1021/jm00368a020 |
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Studies on 1,2,3,-triazoles. 10. Synthesis and antiallergic properties of 9-oxo-1H,9H-benzothiopyrano[2,3-d]-1,2,3-triazoles and their S-oxides Derek R. Buckle, Caroline J. M. Rockell, Harry Smith, and Barbara A. Spicer pp 223 - 227; DOI: 10.1021/jm00368a021 |
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Design and synthesis of tetrahedral intermediate analogs as potential dihydroorotase inhibitors Corey H. Levenson and Rich B. Meyer pp 228 - 232; DOI: 10.1021/jm00368a022 |
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Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogs J. B. Hynes, Y. C. S. Yang, J. E. McGill, S. J. Harmon, and W. L. Washtien pp 232 - 235; DOI: 10.1021/jm00368a023 |
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Novel N-hydroxyguanidine derivatives as anticancer and antiviral agents Anna W. Tai, Eric J. Lien, Michael M. C. Lai, and Tasneem A. Khwaja pp 236 - 238; DOI: 10.1021/jm00368a024 |
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Antileukemic compounds derived by chemical modification of macrocyclic trichothecenes. 2. Derivatives of roridins A and H and verrucarins A and J Bruce B. Jarvis, Jacob O. Midiwo, and Eugene P. Mazzola pp 239 - 244; DOI: 10.1021/jm00368a025 |
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Book Reviews pp 244 - 246; DOI: 10.1021/jm00368a600 |
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Dependence of .beta.-lactamase stability on substructures within .beta.-lactam antibiotics Christopher M. Cimarusti pp 247 - 253; DOI: 10.1021/jm00369a001 |
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5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation H. D. Hollis Showalter, Judith L. Johnson, Leslie M. Werbel, Wilbur R. Leopold, Robert C. Jackson, and Edward F. Elslager pp 253 - 255; DOI: 10.1021/jm00369a002 |
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N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor Kazimir Sestanj, Francesco Bellini, Steven Fung, Nedumparambil Abraham, Adi Treasurywala, Leslie Humber, Nicole Simard-Dequesne, and Dushan Dvornik pp 255 - 256; DOI: 10.1021/jm00369a003 |
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Cardiac glycosides. 1. A systematic study of digitoxigenin D-glycosides Dwight S. Fullerton, Masaru Kihara, Tamboue Deffo, Eitaro Kitatsuji, Khalil Ahmed, Bruce Simat, and Arthur H. L. From pp 256 - 261; DOI: 10.1021/jm00369a004 |
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A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria David R. Friend and George W. Chang pp 261 - 266; DOI: 10.1021/jm00369a005 |
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Synthesis and biological activity of nucleosides and nucleotides related to the antitumor agent 2-.beta.-D-ribofuranosylthiazole-4-carboxamide Prem C. Srivastava, Ganapathi R. Revankar, and Roland K. Robins pp 266 - 269; DOI: 10.1021/jm00369a006 |
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Synthesis and evaluation of a series of 2'-O-acyl derivatives of 9-.beta.-D-arabinofuranosyladenine as antiherpes agents David C. Baker, S. D. Kumar, William J. Waites, Gussie Arnett, William M. Shannon, William I. Higuchi, and W. J. Lambert pp 270 - 274; DOI: 10.1021/jm00369a007 |
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Adenosine deaminase inhibitors. Synthesis of deaza analogs of erythro-9-(2-hydroxy-3-nonyl) adenine Ippolito Antonini, Gloria Cristalli, Palmarisa Franchetti, Mario Grifantini, Sante Martelli, Giulio Lupidi, and Francesca Riva pp 274 - 278; DOI: 10.1021/jm00369a008 |
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Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogs: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyridine against herpes simplex virus type 1 Donald E. Bergstrom, Jerry L. Ruth, P. Anantha Reddy, and Erik De Clercq pp 279 - 284; DOI: 10.1021/jm00369a009 |
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Antiviral activity of C-5 substituted tubercidin analogs Donald E. Bergstrom, Alan J. Brattesani, Mark K. Ogawa, P. Anantha Reddy, Michael J. Schweickert, Jan Balzarini, and Erik De Clercq pp 285 - 292; DOI: 10.1021/jm00369a010 |
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1,4-Dihydro-4-oxopyridinecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent Junichi Matsumoto, Teruyuki Miyamoto, Akira Minamida, Yoshiro Nishimura, Hiroshi Egawa, and Haruki Nishimura pp 292 - 301; DOI: 10.1021/jm00369a011 |
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Structure-activity relationships of sparsomycin and its analogs: octylsparsomycin: The first analog more active than sparsomycin Rob M. J. Liskamp, J. Hans Colstee, Harry C. J. Ottenheijm, Peter Lelieveld, and Wil Akkerman pp 301 - 306; DOI: 10.1021/jm00369a012 |
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Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4,4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid Thomas Hogberg, Ish Khanna, Steven D. Drake, Lester A. Mitscher, and Linus L. Shen pp 306 - 310; DOI: 10.1021/jm00369a013 |
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Structure activity studies on the N-terminal region of glucagon Javier Sueiras-Diaz, Valentine A. Lance, William A. Murphy, and David H. Coy pp 310 - 315; DOI: 10.1021/jm00369a014 |
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Angiotensin II: dependence of hormone affinity on the electronegativity of a single side chain Gaetan Guillemette, Michel Bernier, Paul Parent, Richard Leduc, and Emanuel Escher pp 315 - 320; DOI: 10.1021/jm00369a015 |
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Synthesis of a novel class of heteroaromatic amino acids and their use in the preparation of analogs of luteinizing hormone-releasing hormone John J. Nestor, Bonnie L. Horner, Teresa L. Ho, Gordon H. Jones, Georgia I. McRae, and Brian H. Vickery pp 320 - 325; DOI: 10.1021/jm00369a016 |
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Tri- and tetrapeptide analogs of kinins as potential renal vasodilators Francis R. Pfeiffer, Pamela A. Chambers, Eileen E. Hilbert, Paul W. Woodward, and Dennis M. Ackerman pp 325 - 341; DOI: 10.1021/jm00369a017 |
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Cytochrome P-450 complex formation in the metabolism of phenylalkylamines. 8. Stereoselectivity in metabolic intermediary complex formation with a series of chiral 2-substituted 1-phenyl-2-aminoethanes Ulla B. Paulsen-Soerman, Karl Henrik Joensson, and Bjoern G. A. Lindeke pp 342 - 346; DOI: 10.1021/jm00369a018 |
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Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate Cynthia Dias Selassie, Corwin Hansch, Tasneem A. Khwaja, Cecilia B. Dias, and Stephanie Pentecost pp 347 - 357; DOI: 10.1021/jm00369a019 |
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Studies of the mode of action of antitumor triazenes and triazines. 6. 1-Aryl-3-(hydroxymethyl)-3-methyltriazenes: synthesis, chemistry, and antitumor properties Keith Vaughan, York Tang, Gerard Llanos, Julie K. Horton, Richard J. Simmonds, John A. Hickman, and Malcolm F. G. Stevens pp 357 - 363; DOI: 10.1021/jm00369a020 |
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Potential antitumor agents. 40. Orally active 4,5-disubstituted derivatives of amsacrine William A. Denny, Graham J. Atwell, and Bruce C. Baguley pp 363 - 367; DOI: 10.1021/jm00369a021 |
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Potential antitumor agents. 41. Analogs of amsacrine with electron-donor substituents in the anilino ring Graham J. Atwell, Gordon W. Rewcastle, William A. Denny, Bruce F. Cain, and Bruce C. Baguley pp 367 - 372; DOI: 10.1021/jm00369a022 |
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Dibenz[b,c]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 4. Synthesis and evaluation of 4-(4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-yl)butanol and -butyric acid and related derivatives Lawrence L. Martin, Linda L. Setescak, Theodore C. Spaulding, and Grover C. Helsley pp 372 - 376; DOI: 10.1021/jm00369a023 |
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Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins J. I. DeGraw, P. H. Christie, E. G. Brown, L. F. Kelly, R. L. Kisliuk, Y. Gaumont, and F. M. Sirotnak pp 376 - 380; DOI: 10.1021/jm00369a024 |
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(Imidazolylphenyl)formamidines. A structurally novel class of potent histamine H2 receptor antagonists Arturo Donetti, Enzo Cereda, Elio Bellora, Alberto Gallazzi, Cesare Bazzano, Piercarlo Vanoni, Piero Del Soldato, Rosamaria Micheletti, Ferdinando Pagani, and Antonio Giachetti pp 380 - 386; DOI: 10.1021/jm00369a025 |
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6-Hydroxy-4-[2-di-n-propylaminoethyl]indole: synthesis and dopaminergic actions Joseph G. Cannon, Teresa Lee, Mustafa Ilhan, Jay Koons, and John Paul Long pp 386 - 389; DOI: 10.1021/jm00369a026 |
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Synthesis and evaluation of radioiodinated terminal para-iodophenyl-substituted .alpha.- and .beta.-methyl-branched fatty acids M. M. Goodman, G. Kirsch, and F. F. Knapp pp 390 - 397; DOI: 10.1021/jm00369a027 |
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Phosphorus-nitrogen compounds. 24. Phosphoramide mustard carrier derivatives Lindley A. Cates, Ven Shun Li, Douglas R. Powell, and Dick Van der Helm pp 397 - 401; DOI: 10.1021/jm00369a028 |
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(.+-.)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 3. 2-Phenyl and 2-amino analogs as potential antihypertensive agents Linda L. Setescak, Frederick W. Dekow, Jan M. Kitzen, and Lawrence L. Martin pp 401 - 404; DOI: 10.1021/jm00369a029 |
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A cyclic angiotensin antagonist: [1,8-cysteine)angiotensin II John M. Matsoukas, Martin N. Scanlon, and Graham J. Moore pp 404 - 406; DOI: 10.1021/jm00369a030 |
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Synthesis of certain hydroxy analogs of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes Reza Allahyari, Allen Strother, Ian M. Fraser, and Anthony J. Verbiscar pp 407 - 410; DOI: 10.1021/jm00369a031 |
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Acetylenic nucleosides. Synthesis and biological activities of some 5-ethynylpyrimidine nucleosides Ram A. Sharma, Ivan Kavai, Robert G. Hughes, and Miroslav Bobek pp 410 - 412; DOI: 10.1021/jm00369a032 |
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Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid Irmgard Boettcher, Walter Elger, Gerald Kirsch, Fred Siegmund, and Helmut Wachtel pp 413 - 414; DOI: 10.1021/jm00369a033 |
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Book Reviews pp 415 - 416; DOI: 10.1021/jm00369a600 |
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Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes Daniel H. Rich, Byung Jo Moon, and Scott Harbeson pp 417 - 422; DOI: 10.1021/jm00370a001 |
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Potent and selective antagonists of the antidiuretic responses to arginine-vasopressin based on modifications of [1-(.beta.-mercapto-.beta.,.beta.-pentamethylenepropionic acid), 2-D-isoleucine, 4-valine]arginine-vasopressin at position 4 Maurice Manning, Eleonora Nawrocka, Aleksandra Misicka, Aleksandra Olma, Wieslaw A. Klis, Janny Seto, and Wilbur H. Sawyer pp 423 - 429; DOI: 10.1021/jm00370a002 |
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Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids Corinne G. Wong and Rich B. Meyer pp 429 - 432; DOI: 10.1021/jm00370a003 |
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2,3,4,4a,5,9b-Hexahydro-1H-indeno[1,2-b]pyridines: potential antidepressants Rudolf Kunstmann, Ulrich Lerch, Hermann Gerhards, Margret Leven, and Ulrich Schacht pp 432 - 439; DOI: 10.1021/jm00370a004 |
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Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine Roger N. Hunston, A. Stanley Jones, Christopher McGuigan, Richard T. Walker, Jan Balzarini, and Erik De Clercq pp 440 - 444; DOI: 10.1021/jm00370a005 |
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Synthesis and antitumor activity of cis-dichloroplatinum(II)-N-aminated nucleoside Mitsuaki Maeda, Noriko Abiko, Hiroyuki Uchida, and Takuma Sasaki pp 444 - 449; DOI: 10.1021/jm00370a006 |
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Interactions of antitumor drugs with natural DNA: proton NMR study of binding mode and kinetics Juli Feigon, William A. Denny, Werner Leupin, and David R. Kearns pp 450 - 465; DOI: 10.1021/jm00370a007 |
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NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathways Gerald Zon, Susan Marie Ludeman, Joan A. Brandt, Victoria L. Boyd, Gunay Ozkan, William Egan, and Kai Liu Shao pp 466 - 485; DOI: 10.1021/jm00370a008 |
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Base-catalyzed hydrolysis of 4-hydroperoxycyclophosphamide: evidence for iminocyclophosphamide as an intermediate Richard F. Borch and Kathleen M. Getman pp 485 - 490; DOI: 10.1021/jm00370a009 |
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In situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: proton and phosphorus-31 NMR evidence for equilibration of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and its hydrate in aqueous solution Richard F. Borch, Thomas R. Hoye, and Todd A. Swanson pp 490 - 494; DOI: 10.1021/jm00370a010 |
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Quantitative relationships between .alpha.-adrenergic activity and binding affinity of .alpha.-adrenoceptor agonists and antagonists Pieter B. M. W. M. Timmermans, Adriaan De Jonge, Martin J. M. C. Thoolen, Bob Wilffert, Harry Batink, and Pieter A. Van Zwieten pp 495 - 503; DOI: 10.1021/jm00370a011 |
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.beta.1-Selective adrenoceptor antagonists. 3. 4-Azolyl linked phenoxypropanolamines Peter J. Machin, David N. Hurst, Rachel M. Bradshaw, Leslie C. Blaber, David T. Burden, and Rosemary A. Melarange pp 503 - 509; DOI: 10.1021/jm00370a012 |
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Synthesis, receptor binding, and target-tissue uptake of carbon-11 labeled carbamate derivatives of estradiol and hexestrol Rene Ouellet, Jacques Rousseau, Nicole Brasseur, Johan E. Van Lier, Mirko Diksic, and Gerrit Westera pp 509 - 513; DOI: 10.1021/jm00370a013 |
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Synthesis and physicochemical and neurotoxicity studies of 1-(4-substituted-2,5-dihydroxyphenyl)-2-aminoethane analogs of 6-hydroxydopamine Alice C. Cheng and Neal Castagnoli pp 513 - 520; DOI: 10.1021/jm00370a014 |
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Analgesics of the orvinol type. 19-Deoxy and 6,20-epoxy derivatives Charles W. Hutchins and Henry Rapoport pp 521 - 527; DOI: 10.1021/jm00370a015 |
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Synthesis and antiallergy activity of 10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidines and 10-oxo-10H-pyrido[1,2-a]thieno[3,4-d]pyrimidines David T. Connor, Roderick J. Sorenson, Wiaczeslaw A. Cetenko, Joseph J. Kerbleski, and Francis J. Tinney pp 528 - 530; DOI: 10.1021/jm00370a016 |
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8-Methoxypsoralen-nucleic acid photoreaction. Effect of methyl substitution on pyrone vs. furan photoaddition David Kanne, Henry Rapoport, and John E. Hearst pp 531 - 534; DOI: 10.1021/jm00370a017 |
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(.+-.)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)-(1.alpha.,2.alpha.,3.beta.,5.beta.)-1,2-cyclopentanediol, the carbocyclic analog of tubercidin John A. Secrist, Sarah Jo Clayton, and John A. Montgomery pp 534 - 536; DOI: 10.1021/jm00370a018 |
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Racemic and optically active 2,9-dimethyl-5-(m-hydroxyphenyl)morphans and pharmacological comparison with the 9-demethyl homologs Hiroyoshi Awaya, Everette L. May, Mario D. Aceto, Herbert Merz, Michael E. Rogers, and Louis S. Harris pp 536 - 539; DOI: 10.1021/jm00370a019 |
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Studies on heterocyclic compounds. 6. Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives Sheng Chu Kuo, Li Jiau Huang, and Hideo Nakamura pp 539 - 544; DOI: 10.1021/jm00370a020 |
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Synthesis and biological activity of structural analogs of the anticancer benzophenanthridine alkaloid nitidine chloride Mark Cushman, Prem Mohan, and Edward C. R. Smith pp 544 - 547; DOI: 10.1021/jm00370a021 |
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Synthesis and antitumor activity of some aromatic selenolactones W. C. Groutas, M. C. Theodorakis, W. A. F. Tomkins, G. Herro, and T. Gaynor pp 548 - 550; DOI: 10.1021/jm00370a022 |
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Synthesis and pharmacological activity of some 9-substituted .DELTA.8-tetrahydrocannabinol (THC) analogs Lauri R. Robertson, Richard P. Duffley, Raj K. Razdan, Billy R. Martin, Louis S. Harris, and William L. Dewey pp 550 - 552; DOI: 10.1021/jm00370a023 |
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Book Reviews pp 553 - 556; DOI: 10.1021/jm00370a600 |
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Drug design by the method of receptor fit Peter J. Goodford pp 557 - 564; DOI: 10.1021/jm00371a001 |
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Biomimetic approach to potential benzodiazepine receptor agonists and antagonists Filadelfo Guzman, Michael Cain, Paul Larscheid, Tim Hagen, James M. Cook, Margaret Schweri, Phil Skolnick, and Steven M. Paul pp 564 - 570; DOI: 10.1021/jm00371a002 |
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.alpha.-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on .alpha.-adrenoreceptor activity Christopher B. Chapleo, Peter L. Myers, Richard C. M. Butler, John A. Davis, John C. Doxey, Stanley D. Higgins, Malcolm Myers, Alan G. Roach, Colin F. C. Smith, and et al. pp 570 - 576; DOI: 10.1021/jm00371a003 |
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Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols Rolf W. Hartmann, Aledander Heindl, and Helmut Schoenenberger pp 577 - 585; DOI: 10.1021/jm00371a004 |
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Ibotenic acid analogs. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors Povl Krogsgaard-Larsen, Elsebet O. Nielsen, and David R. Curtis pp 585 - 591; DOI: 10.1021/jm00371a005 |
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2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity Herbert T. Nagasawa, David J. W. Goon, William P. Muldoon, and Richard T. Zera pp 591 - 596; DOI: 10.1021/jm00371a006 |
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Synthesis of pyridine derivatives of L-phenylalanine as antisickling reagents Janina Altman, Marian Gorecki, Meir Wilchek, Joseph R. Votano, and Alexander Rich pp 596 - 600; DOI: 10.1021/jm00371a007 |
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Methotrexate analogs. 19. Replacement of the glutamate side-chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity Andre Rosowsky, Ronald A. Forsch, James H. Freisheim, Richard G. Moran, and Michael Wick pp 600 - 604; DOI: 10.1021/jm00371a008 |
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Methotrexate analogs. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters Andre Rosowsky, Ronald A. Forsch, Cheng Sein Yu, Herbert Lazarus, and G. Peter Beardsley pp 605 - 609; DOI: 10.1021/jm00371a009 |
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3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents Emilio Toja, Domenica Selva, and Pierfranco Schiatti pp 610 - 616; DOI: 10.1021/jm00371a010 |
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Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines Klaus Weinhardt, Colin C. Beard, Charles Dvorak, Michael Marx, John Patterson, Adolph Roszkowski, Margery Schuler, Stefan H. Unger, Paul J. Wagner, and Marshall B. Wallach pp 616 - 627; DOI: 10.1021/jm00371a011 |
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5-Aryl-3-azabicyclo[3.2.0]heptan-5-one ketals, compounds with morphine-like analgesic activity Thomas C. McKenzie, Joseph W. Epstein, William J. Fanshawe, J. Scott Dixon, Arnold C. Osterberg, Lawrence P. Wennogle, Barbara A. Regan, Marc S. Abel, and Laurence R. Meyerson pp 628 - 632; DOI: 10.1021/jm00371a012 |
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Novel opiates and antagonists. 6. 7-Alkyl-6,7-didehydromorphinans James Quick, Patricia Herlihy, and John F. Howes pp 632 - 637; DOI: 10.1021/jm00371a013 |
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Intensely potent morpholinyl anthracyclines Edward M. Acton, George L. Tong, Carol W. Mosher, and Richard L. Wolgemuth pp 638 - 645; DOI: 10.1021/jm00371a014 |
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Substituted (.omega.-aminoalkoxy)stilbene derivatives as a new class of anticonvulsants Ryoji Kikumoto, Akihiro Tobe, Harukazu Fukami, Kunihiro Ninomiya, and Mitsuo Egawa pp 645 - 649; DOI: 10.1021/jm00371a015 |
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Cyheptamide and 3-hydroxy-3-phenacyloxindole structural similarity to diphenylhydantoin as the basis for anticonvulsant activity Penelope W. Codding, Tamara A. Lee, and John F. Richardson pp 649 - 654; DOI: 10.1021/jm00371a016 |
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Phosphorus analogs of .gamma.-aminobutyric acid, a new class of anticonvulsants Lindley A. Cates, Ven Shun Li, Chriss C. Yakshe, Michael O. Fadeyi, Terrance H. Andree, Edward W. Karbon, and Salvatore J. Enna pp 654 - 659; DOI: 10.1021/jm00371a017 |
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.gamma.-Aminobutyric acid esters. I. Synthesis, brain uptake, and pharmacological studies of aliphatic and steroid esters of .gamma.-aminobutyric acid Victor E. Shashoua, James N. Jacob, Richard Ridge, Alexander Campbell, and Ross J. Baldessarini pp 659 - 664; DOI: 10.1021/jm00371a018 |
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2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo Y. Fulmer Shealy, Charles A. Krauth, and W. Russell Laster pp 664 - 670; DOI: 10.1021/jm00371a019 |
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Synthesis and antiviral evaluation of carbocyclic analogs of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines Y. Fulmer Shealy, Joe D. Clayton, Gussie Arnett, and William M. Shannon pp 670 - 674; DOI: 10.1021/jm00371a020 |
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Dopaminergic agonists: comparative actions of amine and sulfonium analogs of dopamine Akihiko Hamada, Yu An Chang, Norman Uretsky, and Duane D. Miller pp 675 - 680; DOI: 10.1021/jm00371a021 |
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Potential inhibitors of nucleotide biosynthesis. 2. Halomethyl ketone derivatives of pyrimidine nucleosides John A. Montgomery, H. Jeanette Thomas, R. Wallace Brockman, and Robert D. Elliott pp 680 - 684; DOI: 10.1021/jm00371a022 |
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Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl]-2-oxo-1-pyrrolidineacetamides, including pramiracetam Donald E. Butler, Ivan C. Nordin, Yvon J. L'Italien, Lynette Zweisler, Paul H. Poschel, and John G. Marriott pp 684 - 691; DOI: 10.1021/jm00371a023 |
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Synthesis of some phosphonates with antiherpetic activity G. D. Diana, E. S. Zalay, U. J. Salvador, F. Pancic, and B. Steinberg pp 691 - 694; DOI: 10.1021/jm00371a024 |
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Substituent effects on reactivity and spectral parameters of cephalosporins Bernard Coene, Andre Schanck, Jean Marie Dereppe, and Maurice Van Meerssche pp 694 - 700; DOI: 10.1021/jm00371a025 |
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Mitomycin C analogs with aryl substituents on the 7-amino group Salah M. Sami, Bhashyam S. Iyengar, Shirley E. Tarnow, William A. Remers, William T. Bradner, and John E. Schurig pp 701 - 708; DOI: 10.1021/jm00371a026 |
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Book Reviews pp 708 - 710; DOI: 10.1021/jm00371a600 |
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Vinylogous amino acid esters: a new class of inactivators for thiol proteases Robert P. Hanzlik and Stewart A. Thompson pp 711 - 712; DOI: 10.1021/jm00372a001 |
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3-Hydroxy-.alpha.-methyltyrosine progenitors, synthesis and evaluation of some (2-oxo-1,3-dioxol-4-yl)methyl esters Walfred S. Saari, Wasyl Halczenko, David W. Cochran, Michael R. Dobrinska, William C. Vincek, David C. Titus, S. Lee Gaul, and Charles S. Sweet pp 713 - 717; DOI: 10.1021/jm00372a002 |
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Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis Eric C. Bigham, Charles E. Gragg, William R. Hall, John E. Kelsey, William R. Mallory, Drew C. Richardson, Charles Benedict, and Paul H. Ray pp 717 - 726; DOI: 10.1021/jm00372a003 |
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Oligonucleotide structural parameters that influence binding of 5'-O-triphosphoadenylyl-(2' .fwdarw. 5')-adenylyl-(2' .fwdarw. 5')-adenosine to the 5'-O-triphosphoadenylyl-(2' .fwdarw. 5')-adenylyl-(2' .fwdarw. 5')-adenosine dependent endoribonuclease: chain length, phosphorylation state, and heterocyclic base Paul F. Torrence, Jiro Imai, Krystyna Lesiak, Jean Claude Jamoulle, and Hiroaki Sawai pp 726 - 733; DOI: 10.1021/jm00372a004 |
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Synthesis and evaluation of 19-aza- and 19-aminoandrostenedione analogs as potential aromatase inhibitors Jane A. Lovett, Michael V. Darby, and Raymond E. Counsell pp 734 - 740; DOI: 10.1021/jm00372a005 |
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Synthesis of thyrotropin-releasing hormone analogs. 1. Complete dissociation of central nervous system effects from thyrotropin-releasing activity Tamas Szirtes, Lajos Kisfaludy, Eva Palosi, and Laszlo Szporny pp 741 - 745; DOI: 10.1021/jm00372a006 |
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Bile acids with a cyclopropyl-containing side chain. 1. Preparation and properties of 3.alpha.,7.beta.-dihydroxy-22,23-methylene-5.beta.-cholan-24-oic acid Roberto Pellicciari, Sergio Cecchetti, Benedetto Natalini, Aldo Roda, Brunella Grigolo, and Adamo Fini pp 746 - 749; DOI: 10.1021/jm00372a007 |
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Formation of a reactive iminium derivative by enzymatic and chemical oxidations of 16-O-acetylvindoline F. Sima Sariaslani, Frances M. Eckenrode, John M. Beale, and John P. Rosazza pp 749 - 754; DOI: 10.1021/jm00372a008 |
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Acetylation of some novel hemicholinium compounds by soluble choline acetyltransferase: structure-activity relationships S. Martin Shreeve, G. B. A. Veitch, and Brian A. Hemsworth pp 754 - 757; DOI: 10.1021/jm00372a009 |
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Synthesis, conformational analysis, and antiarrhythmic properties of 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonan-9-one, 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonane hydroperchlorate, and 7-benzyl-9-phenyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ol hydroperchlorate and derivatives. Single-crystal x-ray diffraction analysis and evidence for chair-chair and chair-boat conformers in the solid state Bruce R. Bailey, K. Darrell Berlin, Elizabeth M. Holt, Benjamin J. Scherlag, Ralph Lazzara, Johannes Brachmann, Dick Van der Helm, Douglas R. Powell, Nantelle S. Pantaleo, and Peter C. Ruenitz pp 758 - 767; DOI: 10.1021/jm00372a010 |
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Hypolipidemic activity of phthalimide derivatives. 7. Structure-activity studies of indazolone analogs Steven D. Wyrick, P. Josee Voorstad, George Cocolas, and Iris H. Hall pp 768 - 772; DOI: 10.1021/jm00372a011 |
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Synthesis of previously inaccessible quinazolines and 1,4-benzodiazepines as potential anticonvulsants Aqeel A. Fatmi, Niteen A. Vaidya, W. B. Iturrian, and C. DeWitt Blanton pp 772 - 778; DOI: 10.1021/jm00372a012 |
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Anticonvulsant activity of some 4-aminobenzamides C. Randall Clark, Martha J. M. Wells, Ricky T. Sansom, George N. Norris, Randy C. Dockens, and William R. Ravis pp 779 - 782; DOI: 10.1021/jm00372a013 |
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In the search for new anticancer drugs. 9. Synthesis and anticancer activity of spin-labeled analogs of N,N:N',N':N",N"-tris(1,2-ethanediyl)phosphoric triamide and N,N:N',N':N",N"-tris(1,2-ethanediyl)phosphorothioic triamide George Sosnovsky and Buddha D. Paul pp 782 - 788; DOI: 10.1021/jm00372a014 |
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Substituent branching in phenethylamine-type hallucinogens: a comparison of 1-[2,5-dimethoxy-4-(2-butyl)phenyl]-2-aminopropane and 1-[2,5-dimethoxy-4-(2-methylpropyl)phenyl]-2-aminopropane Robert A. Oberlender, Paresh J. Kothari, David E. Nichols, and Joseph E. Zabik pp 788 - 792; DOI: 10.1021/jm00372a015 |
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Synthesis of a novel series of (aryloxy)propanolamines: new selective .beta.2-blocking agents Marie Christiane Carre, Alphonse Youlassani, and Paul Caubere pp 792 - 799; DOI: 10.1021/jm00372a016 |
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Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine Minchi Huang, Thomas L. Avery, Raymond L. Blakeley, John A. Secrist, and John A. Montgomery pp 800 - 802; DOI: 10.1021/jm00372a017 |
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Synthesis and biological evaluation of radiolabeled .beta.-ruthenocenylalanine William H. Soine, Clarence E. Guyer, and Furn F. Knapp pp 803 - 806; DOI: 10.1021/jm00372a018 |
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Aporphines. 58. N-(2-Chloroethyl)[8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application Ji Hua Guan, John L. Neumeyer, Crist N. Filer, David G. Ahern, Leslie Lilly, Masayuki Watanabe, Dimitri Grigoriadis, and Philip Seeman pp 806 - 810; DOI: 10.1021/jm00372a019 |
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Topical carbonic anhydrase inhibitors Ronald D. Schoenwald, Mark G. Eller, John A. Dixson, and Charles F. Barfknecht pp 810 - 812; DOI: 10.1021/jm00372a020 |
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2,3-Dimethyl-1,4-naphthoquinone derivatives as bioreductive alkylating agents with crosslinking potential Tai Shun Lin, Ippolito Antonini, Lucille A. Cosby, and Alan C. Sartorelli pp 813 - 815; DOI: 10.1021/jm00372a021 |
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Bicyclic lactam inhibitors of angiotensin converting enzyme Jeffrey W. H. Watthey, Terrence Gavin, and Mahesh Desai pp 816 - 818; DOI: 10.1021/jm00372a022 |
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Book Reviews pp 818 - 818; DOI: 10.1021/jm00372a600 |
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Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols Rolf W. Hartmann, Alexander Heindl, Walter Schwarz, and Helmut Schoenenberger pp 819 - 824; DOI: 10.1021/jm00373a001 |
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Structural correlations of choline acetyltransferase inhibitors: trans-N-(carboxymethyl)-4-(.beta.-1-naphthylvinyl)pyridinium bromide and cis-N-(2-aminoethyl)-4-(.beta.-1-naphthylvinyl)-3-methylpyridinium bromide hydrobromide Andrew Y. Chweh, John F. DeBernardis, Jerome F. Siuda, Nelson G. Rondan, Jaime E. Abola, and Donald J. Abraham pp 825 - 830; DOI: 10.1021/jm00373a002 |
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.beta.-Adrenergic blocking agents: substituted phenylalkanolamines. Effect of side-chain length on .beta.-blocking potency in vitro Walter Fuhrer, Franz Ostermayer, Markus Zimmermann, Max Meier, and Hedi Mueller pp 831 - 836; DOI: 10.1021/jm00373a003 |
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A photoaffinity reagent to label the opiate receptors of guinea pig ileum and mouse vas deferens Toshiyuki Fujioka, Tohru Matsunaga, Hitoshi Nakayama, Yuichi Kanaoka, Yujiro Hayashi, Kenji Kangawa, and Hisayuki Matsuo pp 836 - 840; DOI: 10.1021/jm00373a004 |
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(Acylaryloxy)acetic acid diuretics. 5. [(2-Alkyl- and 2,2-disubstituted-1,3-dioxo-5-indanyl)oxy]acetic acids O. W. Woltersdorf, S. J. DeSolms, G. E. Stokker, and E. J. Cragoe pp 840 - 845; DOI: 10.1021/jm00373a005 |
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Synthesis of potent heptapeptide analogs of cholecystokinin Botond Penke, Ferenc Hajnal, Janos Lonovics, Gabor Holzinger, Tibor Kadar, Gyula Telegdy, and Jean Rivier pp 845 - 849; DOI: 10.1021/jm00373a006 |
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Histamine H2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities Isao Yanagisawa, Yasufumi Hirata, and Yoshio Ishii pp 849 - 857; DOI: 10.1021/jm00373a007 |
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3,4-Catechol derivative of propranolol, a minor dihydroxylated metabolite Wendel L. Nelson, Michael J. Bartels, Patrick J. Bednarski, Shoufang Zhang, Karen Messick, J. S. Horng, and Robert R. Ruffolo pp 857 - 861; DOI: 10.1021/jm00373a008 |
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Synthesis, characterization, and properties, of a group of platinum(IV) complexes Robert J. Brandon and James C. Dabrowiak pp 861 - 865; DOI: 10.1021/jm00373a009 |
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Identification of an acridine photoaffinity probe for trypanocidal action William J. Firth, Andrew Messa, Robert Reid, Rung Chou Wang, Charles L. Watkins, and Lerena W. Yielding pp 865 - 870; DOI: 10.1021/jm00373a010 |
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Tumor inhibitory triazenes. 3. Dealkylation within an homologous series and its relation to antitumor activity Derry E. V. Wilman, Peter J. Cox, Phyllis M. Goddard, Leigh I. Hart, Kanti Merai, and David R. Newell pp 870 - 874; DOI: 10.1021/jm00373a011 |
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Troponoids. 6. Troponylpiperazines: a new class of dopamine agonists Jehan Bagli, T. Bogri, and Katherine Voith pp 875 - 881; DOI: 10.1021/jm00373a012 |
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Sulfur analogs of psychotomimetic agents. 30. Ethyl homologs of mescaline and their monothioanalogs Peyton Jacob and Alexander T. Shulgin pp 881 - 888; DOI: 10.1021/jm00373a013 |
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Methotrexate analogs. 22. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates Andre Rosowsky, Ronald A. Forsch, James H. Freisheim, John Galivan, and Michael Wick pp 888 - 893; DOI: 10.1021/jm00373a014 |
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Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones J. Heeres, L. J. J. Backx, and J. Van Cutsem pp 894 - 900; DOI: 10.1021/jm00373a015 |
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A general distance-geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors Arup K. Ghose and Gordon M. Crippen pp 901 - 914; DOI: 10.1021/jm00373a016 |
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Synthesis of potential antifilarial agents. 1. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl and aryl ureas Siya Ram, Mike Skinner, Doug Kalvin, Dean S. Wise, Leroy B. Townsend, John W. McCall, Don Worth, Don Ortwine, and Leslie M. Werbel pp 914 - 917; DOI: 10.1021/jm00373a017 |
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Development of an affinity ligand for purification of .alpha.2-adrenoceptors from human platelet membranes R. M. DeMarinis, A. J. Krog, D. H. Shah, J. Lafferty, K. G. Holden, J. P. Hieble, W. D. Matthews, J. W. Regan, R. J. Lefkowitz, and M. G. Caron pp 918 - 921; DOI: 10.1021/jm00373a018 |
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Catechol derivatives of 6-aminobenzocycloheptene: assessment of dopaminergic effects Joseph G. Cannon, Jonathan P. Pease, John Paul Long, and Jan Flynn pp 922 - 923; DOI: 10.1021/jm00373a019 |
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Biological activity and a modified synthesis of 8-amino-3-.beta.-D-ribofuranosyl-1,2,4-triazolo[4,3-.alpha.]pyrazine, an isomer of formycin Stewart W. Schneller, Robert D. Thompson, Joseph G. Cory, Ray A. Olsson, Erik De Clercq, In Kyung Kim, and Peter K. Chiang pp 924 - 928; DOI: 10.1021/jm00373a020 |
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Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds Rokbert G. Christiansen, Helmut C. Neumann, U. Joseph Salvador, Malcolm R. Bell, H. Philip Schane, John E. Creange, Gordon O. Potts, and A. J. Anzalone pp 928 - 931; DOI: 10.1021/jm00373a021 |
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Book Reviews pp 931 - 942; DOI: 10.1021/jm00373a600 |
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Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin Bruce E. Maryanoff, David F. McComsey, Michael J. Costanzo, Paulette E. Setler, Joseph F. Gardocki, Richard P. Shank, and Craig R. Schneider pp 943 - 946; DOI: 10.1021/jm00374a001 |
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Synthetic CNS agents. 1. (.+-.)-1,2,3,4,4a,5,10,10a-Octahydro-5,10[1',2']-benzenobenz[g]isoquinoline hydrochloride. A new, highly potent, potential antidepressant P. Rajagopalan pp 946 - 947; DOI: 10.1021/jm00374a002 |
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Preparation and antibacterial activities of new 1,2,3-diazaborine derivatives and analogs Maximilian A. Grassberger, Friederike Turnowsky, and Johannes Hildebrandt pp 947 - 953; DOI: 10.1021/jm00374a003 |
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Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines Francis Johnson, K. M. R. Pillai, Arthur P. Grollman, Lucy Tseng, and Masaru Takeshita pp 954 - 958; DOI: 10.1021/jm00374a004 |
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6-Methylangelicins: a new series of potential photochemotherapeutic agents for the treatment of psoriasis A. Guiotto, P. Rodighiero, P. Manzini, G. Pastorini, F. Bordin, F. Baccichetti, F. Carlassare, D. Vedaldi, and F. Dall'Acqua pp 959 - 967; DOI: 10.1021/jm00374a005 |
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Design, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids D. J. Abraham, P. E. Kennedy, A. S. Mehanna, D. C. Patwa, and F. L. Williams pp 967 - 978; DOI: 10.1021/jm00374a006 |
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[(E)-1-[123I]Iodo-1-penten-5-yl]triphenylphosphonium iodide: convenient preparation of a potentially useful myocardial perfusion agent P. C. Srivastava and F. F. Knapp pp 978 - 981; DOI: 10.1021/jm00374a007 |
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Isomeric N-methyl-7-deazaguanines: synthesis, structural assignment, and inhibitory activity on xanthine oxidase Frank Seela, Werner Bussmann, Andreas Goetze, and Helmut Rosemeyer pp 981 - 985; DOI: 10.1021/jm00374a008 |
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Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-.beta.-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyrimidin-7-ones Pier Giovanni Baraldi, Daniele Simoni, Vittorio Periotto, Stefano Manfredini, Mario Guarneri, Roberto Manservigi, and Enzo Cassai pp 986 - 990; DOI: 10.1021/jm00374a009 |
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.beta.-Lapachone: synthesis of derivatives and activities in tumor models Karl Schaffner-Sabba, Karl H. Schmidt-Ruppin, Walter Wehrli, Alfred R. Schuerch, and Jan W. F. Wasley pp 990 - 994; DOI: 10.1021/jm00374a010 |
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cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-phenyl-2H-pyrazino[2,1-a]isoquinoline: a new atypical antidepressant Ronald C. Griffith, Robert J. Gentile, Roger C. Robichaud, and Jerry Frankenheim pp 995 - 1003; DOI: 10.1021/jm00374a011 |
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C1-Methylated 5-hydroxy-2-(dipropylamino)tetralins: central dopamine-receptor stimulating activity Uli Hacksell, Anette M. Johansson, Lars Erik Arvidsson, J. Lars G. Nilsson, Stephan Hjorth, Arvid Carlsson, Hakan Wikstroem, Domingo Sanchez, and Per Lindberg pp 1003 - 1007; DOI: 10.1021/jm00374a012 |
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[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action Sheung Tsam Kam, William L. Matier, Khuong X. Mai, Cynthia Barcelon-Yang, Robert J. Borgman, John P. O'Donnell, Herman F. Stampfli, Check Y. Sum, William G. Anderson, and et al. pp 1007 - 1016; DOI: 10.1021/jm00374a013 |
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Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: high-ceiling diuretics with uricosuric activity Jacob J. Plattner, Anthony K. L. Fung, James A. Parks, Richard J. Pariza, Steven R. Crowley, Andre G. Pernet, Paul R. Bunnell, and Patrick W. Dodge pp 1016 - 1026; DOI: 10.1021/jm00374a014 |
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Synthesis and antiviral/antitumor activities of certain pyrazolo[3,4-d]pyrimidine-4(5H)-selone nucleosides and related compounds Bheemarao G. Ugarkar, Howard B. Cottam, Patricia A. McKernan, Roland K. Robins, and Ganapathi R. Revankar pp 1026 - 1030; DOI: 10.1021/jm00374a015 |
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Resolved 3-(3-Hydroxyphenyl)-N-n-propylpiperidine and its analogs: central dopamine receptor activity Haakan Wikstroem, Domingo Sanchez, Per Lindberg, Uli Hacksell, Lars Erik Arvidsson, Anette M. Johnsson, Seth Olof Thorberg, J. Lars G. Nilsson, and Kjell Svensson pp 1030 - 1036; DOI: 10.1021/jm00374a016 |
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Selective delivery of cytotoxic compounds to cells by the LDL pathway Raymond A. Firestone, Judith M. Pisano, J. R. Falck, Michael M. McPhaul, and Monty Krieger pp 1037 - 1043; DOI: 10.1021/jm00374a017 |
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A reappraisal of the effect upon thymidine kinase of thymidine derivatives carrying large groups at the 5'-position S. Elaine Barrie, Lawrence C. Davies, John A. Stock, and Kenneth R. Harrap pp 1044 - 1047; DOI: 10.1021/jm00374a018 |
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Structure-activity, theoretical, and x-ray studies on the intramolecular interactions in a series of novel histamine H2 receptor antagonists William C. Lumma Jr., John J. Baldwin, John B. Bicking, William A. Bolhofer, Jacob M. Hoffman, Brian T. Phillips, Charles M. Robb, Mary Lou Torchiana, H. B. Schlegel, and et al. pp 1047 - 1052; DOI: 10.1021/jm00374a019 |
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Potential antitumor agents. 42. Structure-activity relationships for acridine-substituted dimethyl phosphoramidate derivatives of 9-anilinoacridine Gordon W. Rewcastle, Graham J. Atwell, Bruce C. Baguley, and William A. Denny pp 1053 - 1056; DOI: 10.1021/jm00374a020 |
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Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride (LY 156758), a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity Charles D. Jones, Mary G. Jevnikar, Andrew J. Pike, Mary K. Peters, Larry J. Black, Allen R. Thompson, Julie F. Falcone, and James A. Clemens pp 1057 - 1066; DOI: 10.1021/jm00374a021 |
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Structure-activity studies on antidepressant 2,2-diarylethylamines Bruce E. Maryanoff, Samuel O. Nortey, and Joseph F. Gardocki pp 1067 - 1071; DOI: 10.1021/jm00374a022 |
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Radiohalogen-labeled imaging agents. 3. Compounds for measurement of brain blood flow by emission tomography Thornton Sargent, Alexander T. Shulgin, and Chester A. Mathis pp 1071 - 1077; DOI: 10.1021/jm00374a023 |
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Antihypertensives. N-1H-Pyrrol-1-yl-3-pyridazinamines Elvio Bellasio, Ambrogio Campi, Nunzio Di Mola, and Emiliana Baldoli pp 1077 - 1083; DOI: 10.1021/jm00374a024 |
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Syntheses and anthelmintic activity of alkyl 5(6)-(substituted carbamoyl)- and 5(6)-(disubstituted carbamoyl)benzimidazole-2-carbamates and related compounds Shiv Kumar, Manju Seth, Amiya P. Bhaduri, Pradeep K. S. Visen, Anuradha Misra, Suman Gupta, Nigar Fatima, Jagdish C. Katiyar, Ranjeet K. Chatterjee, and Amiya B. Sen pp 1083 - 1089; DOI: 10.1021/jm00374a025 |
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Synthesis and pharmacological evaluation of an 8.beta.-bis(2-chloroethyl)amino opiate as a nonequilibrium opioid receptor probe Sunan Fang, K. H. Bell, and P. S. Portoghese pp 1090 - 1092; DOI: 10.1021/jm00374a026 |
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The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system Larry D. Heimark and William F. Trager pp 1092 - 1095; DOI: 10.1021/jm00374a027 |
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2,5-Anhydro-1-deoxy-1-phosphono-D-altritol, an isosteric analog of .alpha.-D-ribofuranose 1-phosphate Rich B. Meyer, Thomas E. Stone, and Pradipta K. Jesthi pp 1095 - 1098; DOI: 10.1021/jm00374a028 |
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Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure James A. Bristol, Ila Sircar, Walter H. Moos, Dale B. Evans, and Ronald E. Weishaar pp 1099 - 1101; DOI: 10.1021/jm00375a001 |
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Oxidation of sparteines by cytochrome P-450: evidence against the formation of N-oxides F. Peter Guengerich pp 1101 - 1103; DOI: 10.1021/jm00375a002 |
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Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships Mark P. Wentland, Denis M. Bailey, James B. Cornett, Richard A. Dobson, Ronald G. Powles, and Roland B. Wagner pp 1103 - 1108; DOI: 10.1021/jm00375a003 |
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Synthesis and evaluation of substituted 2-phenylcyclobutylamines as analogs of hallucinogenic phenethylamines: lack of LSD-like biological activity David E. Nichols, Kiran P. Jadhav, Robert A. Oberlender, Joseph E. Zabik, Josef F. Bossart, Akihiko Hamada, and Duane D. Miller pp 1108 - 1111; DOI: 10.1021/jm00375a004 |
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Benzylamines: synthesis and evaluation of antimycobacterial properties Wolfgang R. Meindl, Erwin Von Angerer, Helmut Schoenenberger, and Gotthard Ruckdeschel pp 1111 - 1118; DOI: 10.1021/jm00375a005 |
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Synthesis and biological activity of certain 3,4-disubstituted pyrazolo[3,4-d]pyrimidine nucleosides Howard B. Cottam, Charles R. Petrie, Patricia A. McKernan, Richard J. Goebel, N. Kent Dalley, Richard B. Davidson, Roland K. Robins, and Ganapathi R. Revankar pp 1119 - 1127; DOI: 10.1021/jm00375a006 |
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Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols John M. Evans, Charles S. Fake, Thomas C. Hamilton, Robert H. Poyser, and Graham A. Showell pp 1127 - 1131; DOI: 10.1021/jm00375a007 |
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Steroids. 2. Synthesis of C-18 functionalized steroids via the Smith-Hughes route K. M. R. Pillai, W. V. Murray, I. Shooshani, D. L. Williams, D. Gordon, S. Y. Wang, and Francis Johnson pp 1131 - 1137; DOI: 10.1021/jm00375a008 |
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Synthesis and neuroleptic activity of N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfonamidobenzamides Masaru Ogata, Hiroshi Matsumoto, Shiro Kida, Teruo Shiomi, Masami Eigyo, and Katsumi Hirose pp 1137 - 1141; DOI: 10.1021/jm00375a009 |
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Synthesis and antiarrhythmic activity of new 1-[1-[2-[3-{alkylamino}-2-hydroxypropoxy]phenyl]vinyl]-1H-imidazoles and related compounds Masaru Ogata, Hiroshi Matsumoto, Kimio Takahashi, Sumio Shimizu, Shiro Kida, Motohiko Ueda, Sadatoshi Kimoto, and Masao Haruna pp 1142 - 1149; DOI: 10.1021/jm00375a010 |
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Synthesis and antidepressant activity of 4-aryltetrahydrothieno[2,3-c]pyridine derivatives Claus S. Schneider, Karl H. Weber, Helmut Daniel, Wolf D. Bechtel, and Karin Boeke-Kuhn pp 1150 - 1155; DOI: 10.1021/jm00375a011 |
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Synthesis, spectral analysis, and mutagenicity of 1-, 3-, and 6-nitrobenzo[a]pyrene M. W. Chou, R. H. Heflich, D. A. Casciano, D. W. Miller, J. P. Freeman, F. E. Evans, and P. P. Fu pp 1156 - 1161; DOI: 10.1021/jm00375a012 |
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Potential antitumor agents: synthesis and biological properties of aliphatic amino acid 9-hydroxyellipticinium derivatives Christian Auclair, Emmanuelle Voisin, Helene Banoun, Claude Paoletti, Jean Bernadou, and Bernard Meunier pp 1161 - 1166; DOI: 10.1021/jm00375a013 |
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Synthesis and kinetic studies of protease substrates containing the 1-methyl-6-aminoquinolinium ion as a fluorogenic leaving group Patricia Andrade-Gordon, David Gordon, Paul J. Brynes, and Cheng Wen Wu pp 1166 - 1170; DOI: 10.1021/jm00375a014 |
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Luteinizing hormone-releasing hormone antagonists containing very hydrophobic amino acids John J. Nestor, Ram Tahilramani, Teresa L. Ho, Georgia I. McRae, and Brian H. Vickery pp 1170 - 1174; DOI: 10.1021/jm00375a015 |
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Analogs of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain A. Wissner, P. E. Sum, R. E. Schaub, C. A. Kohler, and B. M. Goldstein pp 1174 - 1181; DOI: 10.1021/jm00375a016 |
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Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines Walfred S. Saari, Wasyl Halczenko, Joel R. Huff, James P. Guare, Cecilia A. Hunt, William C. Randall, Victor J. Lotti, and George G. Yarbrough pp 1182 - 1185; DOI: 10.1021/jm00375a017 |
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Cyclic melanotropins. 5. Importance of the C-terminal tripeptide (Lys-Pro-Val) Wayne L. Cody, Brian C. Wilkes, Brian J. Muska, Victor J. Hruby, Ana Maria de L. Castrucci, and Mac E. Hadley pp 1186 - 1190; DOI: 10.1021/jm00375a018 |
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Solution conformations of barbituric acid derivatives: a 3J(13C,1H) NMR study F. Ivy Carroll, Anita H. Lewin, Emily E. Williams, Jack A. Berdasco, and Charles G. Moreland pp 1191 - 1195; DOI: 10.1021/jm00375a019 |
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Derivatives of 2-methyl-1,4-naphthoquinone as substrates and inhibitors of the vitamin K-dependent carboxylase Madhup K. Dhaon, S. R. Lehrman, D. H. Rich, J. A. Engelke, and J. W. Suttie pp 1196 - 1201; DOI: 10.1021/jm00375a020 |
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Nonquaternary cholinesterase reactivators. 2. .alpha.-Heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro Richard A. Kenley, Clifford D. Bedford, Oliver D. Dailey, Robert A. Howd, and Alexi Miller pp 1201 - 1211; DOI: 10.1021/jm00375a021 |
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Benzisoxazolones: antimicrobial and antileukemic activity W. Wierenga, B. R. Evans, and G. E. Zurenko pp 1212 - 1215; DOI: 10.1021/jm00375a022 |
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Synthesis and pharmacological evaluation of indanpropionic acids as uterine relaxants Donald T. Witiak, Ahmed M. Hassan, Franziska R. Del Vecchio, Richard J. Brumbaugh, and Ralf G. Rahwan pp 1215 - 1219; DOI: 10.1021/jm00375a023 |
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Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans Erno Mohacsi, Tom Hayes, and Jerry Sepinwall pp 1219 - 1222; DOI: 10.1021/jm00375a024 |
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Synthesis and antitumor evaluation of some nitrosourea and nitrogen mustard amino acid derivatives Marc Rodriguez, Jean Louis Imbach, and Jean Martinez pp 1222 - 1225; DOI: 10.1021/jm00375a025 |
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Synthesis and antibacterial activity of 2-[(methoxycarbonyl)methylene]cephalosporins C. U. Kim, P. F. Misco, U. J. Haynes, and D. N. McGregor pp 1225 - 1229; DOI: 10.1021/jm00375a026 |
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Vitamin K dependent carboxylation: synthesis and biological properties of tetrazolyl analogs of pentapeptidic substrates Joelle Dubois, Sonia Bory, Michel Gaudry, and Andree Marquet pp 1230 - 1233; DOI: 10.1021/jm00375a027 |
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Preferred conformers for the pharmacologically typical and atypical antipodes of phenylmorphan opiates Mark Froimowitz pp 1234 - 1237; DOI: 10.1021/jm00375a028 |
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Book Reviews pp 1237 - 1238; DOI: 10.1021/jm00375a600 |
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New perspectives on gut peptides Richard J. Miller pp 1239 - 1245; DOI: 10.1021/jm00376a001 |
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Heterocyclic analogs of chlorcyclizine with potent hypolipidemic activity Michael J. Ashton, Alan Ashford, Anthony H. Loveless, David Riddell, John Salmon, and Gregory V. W. Stevenson pp 1245 - 1253; DOI: 10.1021/jm00376a002 |
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Nitrogen bridgehead compounds. 44. New antiallergic 4H-pyrido[1,2-a]pyrimidin-4-ones. 4 Istvan Hermecz, Agnes Horvath, Zoltan Meszaros, Christine De Vos, and Ludovic Rodriguez pp 1253 - 1259; DOI: 10.1021/jm00376a003 |
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Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase Sanford Goldstein, Alfonso L. Pogolotti, Edward P. Garvey, and Daniel V. Santi pp 1259 - 1262; DOI: 10.1021/jm00376a004 |
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A mechanism for the addition of multiple moles of glutamate by folylpolyglutamate synthetase Richard G. Moran, Paul D. Colman, Ronald A. Forsch, and Andre Rosowsky pp 1263 - 1267; DOI: 10.1021/jm00376a005 |
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N-Allyl analogs of phencyclidine: chemical synthesis and pharmacological properties Asher Kalir, Shoshana Teomy, Adina Amir, P. Fuchs, Sung A. Lee, Elzbieta J. Holsztynska, Wieslaw Rocki, and Edward F. Domino pp 1267 - 1271; DOI: 10.1021/jm00376a006 |
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Conformationally restrained fentanyl analogs. 2. Synthesis and analgetic evaluation of perhydro-1,6-naphthyridin-2-ones Ronald F. Borne, E. Kim Fifer, and I. W. Waters pp 1271 - 1275; DOI: 10.1021/jm00376a007 |
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Preparation of 7-(1,3,4-oxadiazolyl)-6,14-endo-etheno-6,7,8,14-tetrahydrothebaines and related compounds as potential analgesics Kenneth W. Bentley, Michael Burton, and Barrie C. Uff pp 1276 - 1280; DOI: 10.1021/jm00376a008 |
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Dichloro[1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum(II) complexes: an approach to develop compounds with a specific effect on the hormone-dependent mammary carcinoma Beate Wappes, Margaretha Jennerwein, Erwin Von Angerer, Helmut Schoenenberger, Juergen Engel, Martin Berger, and Karl Heinz Wrobel pp 1280 - 1286; DOI: 10.1021/jm00376a009 |
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Synthesis and evaluation of (17.alpha.,20E)-21-[125I]iodo-19-norpregna-1,3,5(10),20-tetraene-3,17-diol and (17.alpha.,20E)-21-[125I]iodo-11.beta.-methoxy-19-norpregna-1,3,5(10),20-tetraene-3,17-diol [17.alpha.-iodovinyl)estradiol derivatives] as high specific activity potential radiopharmaceuticals Iwao Nakatsuka, Nelson L. Ferreira, W. C. Eckelman, B. E. Francis, W. J. Rzeszotarski, R. E. Gibson, E. M. Jagoda, and R. C. Reba pp 1287 - 1291; DOI: 10.1021/jm00376a010 |
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Synthesis and .beta.-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers Mohamed Bouzoubaa, Gerard Leclerc, Nicole Decker, Jean Schwartz, and Guy Andermann pp 1291 - 1294; DOI: 10.1021/jm00376a011 |
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Synthesis and in vitro biological evaluation of L-alanosinyl-5-aminoimidazole-4-carboxylic acid ribonucleoside Paolo Strazzolini, Adriano Malabarba, Pietro Ferrari, Maria Grandi, and Bruno Cavalleri pp 1295 - 1299; DOI: 10.1021/jm00376a012 |
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7-(Ethoxycarbonyl)-6,8-dimethyl-2-phenyl-1(2H)-phthalazinone derivatives: synthesis and inhibitory effects on platelet aggregation Akiko Sugimoto, Hiromichi Tanaka, Yukuo Eguchi, Shigeru Ito, Yoshimi Takashima, and Masayuki Ishikawa pp 1300 - 1305; DOI: 10.1021/jm00376a013 |
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A water-soluble cholesteryl-containing Tris-galactoside: synthesis, properties, and use in directing lipid-containing particles to the liver H. J. M. Kempen, C. Hoes, J. H. Van Boom, H. H. Spanjer, J. De Lange, A. Langendoen, and T. J. C. Van Berkel pp 1306 - 1312; DOI: 10.1021/jm00376a014 |
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Molecular analysis of hexahydro-1H-indeno[1,2-b]pyridines: potential antidepressants Rudolf Kunstmann and Gabriele Fischer pp 1312 - 1316; DOI: 10.1021/jm00376a015 |
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Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives David A. Walsh, Mark C. Sleevi, and Lawrence F. Sancilio pp 1317 - 1321; DOI: 10.1021/jm00376a016 |
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Synthesis and murine antineoplastic activity of bis[carbamoyloxymethyl] derivatives of pyrrolo[2,1-a]isoquinoline Wayne K. Anderson, Howard L. McPherson, James S. New, and Arvela C. Rick pp 1321 - 1325; DOI: 10.1021/jm00376a017 |
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Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different .mu. receptor subtypes in different tissues L. M. Sayre, D. L. Larson, A. E. Takemori, and P. S. Portoghese pp 1325 - 1335; DOI: 10.1021/jm00376a018 |
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Latent inhibitors of aldehyde dehydrogenase as alcohol deterrent agents Herbert T. Nagasawa, James A. Elberling, and Eugene G. DeMaster pp 1335 - 1339; DOI: 10.1021/jm00376a019 |
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6,7-Dihydroxy-3-chromanamine: synthesis and pharmacological activity of an oxygen isostere of the dopamine agonist Alan S. Horn, B. Kaptein, T. B. A. Mulder, J. B. de Vries, and H. Wynberg pp 1340 - 1343; DOI: 10.1021/jm00376a020 |
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Total chemical synthesis and antitumor evaluation of 4-demethoxy-10,10-dimethyldaunomycin Jose Alexander, Ish Khanna, Daniel Lednicer, Lester A. Mitscher, Tarik Veysoglu, Zbigniew Wielogorski, and Richard L. Wolgemuth pp 1343 - 1347; DOI: 10.1021/jm00376a021 |
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Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides David M. Stout, W. L. Matier, Cynthia Barcelon-Yang, Robert D. Reynolds, and Barry S. Brown pp 1347 - 1350; DOI: 10.1021/jm00376a022 |
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Inhibition of renin by substrate analog inhibitors containing the olefinic amino acid 5(S)-amino-7-methyl-3(E)-octenoic acid Rodney L. Johnson pp 1351 - 1354; DOI: 10.1021/jm00376a023 |
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Antihypertensive activities of phenyl aminoethyl sulfides, a class of synthetic substrates for dopamine .beta.-hydroxylase Stephen R. Padgette, Heath H. Herman, Jin Hee Han, Stanley H. Pollock, and Sheldon W. May pp 1354 - 1357; DOI: 10.1021/jm00376a024 |
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Carbocyclic analogs of xylofuranosylpurine nucleosides. Synthesis and antitumor activity Robert Vince, Jay Brownell, and Susan Daluge pp 1358 - 1360; DOI: 10.1021/jm00376a025 |
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Activities of morphinone and N-(cyclopropylmethyl)normorphinone at opioid receptors Sunan Fang, A. E. Takemori, and P. S. Portoghese pp 1361 - 1363; DOI: 10.1021/jm00376a026 |
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Mesoionic xanthine analogs: antagonists of adenosine receptors Richard A. Glennon, Shanaz M. Tejani-Butt, William Padgett, and John W. Daly pp 1364 - 1367; DOI: 10.1021/jm00376a027 |
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Synthesis of a tricyclic aphidicolin analog which inhibits DNA synthesis in vitro John E. McMurry and Thomas R. Webb pp 1367 - 1369; DOI: 10.1021/jm00376a028 |
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Activity of novel aminocannabinoids in baboons H. Edery, G. Porath, R. Mechoulam, N. Lander, M. Srebnik, and N. Lewis pp 1370 - 1373; DOI: 10.1021/jm00376a029 |
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Book Reviews pp 1373 - 1378; DOI: 10.1021/jm00376a600 |
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Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogs David A. Walsh, H. Wayne Moran, Dwight A. Shamblee, Ibrahim M. Uwaydah, William J. Welstead, Lawrence F. Sancilio, and Warren N. Dannenburg pp 1379 - 1388; DOI: 10.1021/jm00377a001 |
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Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides Ganapathi R. Revankar, Pranab K. Gupta, Alexander D. Adams, N. Kent Dalley, Patricia A. McKernan, P. Dan Cook, Peter G. Canonico, and Roland K. Robins pp 1389 - 1396; DOI: 10.1021/jm00377a002 |
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(1,3-Dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones. A series of novel central nervous system depressants Donald E. Butler, Lawrence D. Wise, and Horace A. DeWald pp 1396 - 1400; DOI: 10.1021/jm00377a003 |
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Actinidin hydrolysis of substituted-phenyl hippurates: a quantitative structure-activity relationship and graphics comparison with hydrolysis by papain Angelo Carotti, Corwin Hansch, Monica M. Mueller, and Jeffrey M. Blaney pp 1401 - 1405; DOI: 10.1021/jm00377a004 |
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Synthesis and biological actions of highly potent and prolonged acting biotin-labeled melanotropins Dhirendra N. Chaturvedi, James J. Knittel, Victor J. Hruby, Ana Maria de L. Castrucci, and Mac E. Hadley pp 1406 - 1410; DOI: 10.1021/jm00377a005 |
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Investigations on the chemistry of berbanes. 10. Synthesis of raunescinone analogs with hypotensive and antihypertensive activity Istvan Toth, Lajos Szabo, Gabriella Bozsar, Csaba Szantay, Laszlo Szekeres, and Julius G. Papp pp 1411 - 1415; DOI: 10.1021/jm00377a006 |
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Synthesis and antiviral activity of carbocyclic analogs of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines Y. Fulmer Shealy, C. Allen O'Dell, W. M. Shannon, and Gussie Arnett pp 1416 - 1421; DOI: 10.1021/jm00377a007 |
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Studies on synthesis and anticancer activity of selected N-(2-fluoroethyl)-N-nitrosoureas Thomas P. Johnston, Conrad L. Kussner, Ronald L. Carter, Jerry L. Frye, Nancita R. Lomax, Jacqueline Plowman, and V. L. Narayanan pp 1422 - 1426; DOI: 10.1021/jm00377a008 |
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Structure-activity relationship of the ficin hydrolysis of phenyl hippurates. Comparison with papain, actinidin, and bromelain Angelo Carotti, Giovanni Casini, and Corwin Hansch pp 1427 - 1431; DOI: 10.1021/jm00377a009 |
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Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2[(hydroxyimino)methyl]imidazoles Clifford D. Bedford, Ralph N. Harris, Robert A. Howd, Alexi Miller, Harold W. Nolen, and Richard A. Kenley pp 1431 - 1438; DOI: 10.1021/jm00377a010 |
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2-Phenylindoles. Relationship between structure, estrogen receptor affinity, and mammary tumor inhibiting activity in the rat Erwin Von Angerer, Jelica Prekajac, and Josef Strohmeier pp 1439 - 1447; DOI: 10.1021/jm00377a011 |
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A novel peptide delivery system involving peptidase activated prodrugs as antimicrobial agents. Synthesis and biological activity of peptidyl derivatives of 5-fluorouracil William D. Kingsbury, Jeffrey C. Boehm, Rajanikant J. Mehta, Sarah F. Grappel, and Charles Gilvarg pp 1447 - 1451; DOI: 10.1021/jm00377a012 |
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N-Benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties Derek R. Buckle, D. James Outred, Harry Smith, and Barbara A. Spicer pp 1452 - 1457; DOI: 10.1021/jm00377a013 |
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Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque Denis M. Bailey, C. George DeGrazia, Stephanie J. Hoff, Patsy L. Schulenberg, John R. O'Connor, Donald A. Paris, and Andrew McKenzie Slee pp 1457 - 1464; DOI: 10.1021/jm00377a014 |
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Covalent binding of isomeric 7-(2,3-epoxypropoxy)actinomycin D to DNA Sisir K. Sengupta, Joanne Blondin, and Josephine Szabo pp 1465 - 1470; DOI: 10.1021/jm00377a015 |
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Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones Bansi Lal, Alihussein Nomanbhai Dohadwalla, Nandkumar Keshav Dadkar, Adolf D'Sa, and Noel John De Souza pp 1470 - 1480; DOI: 10.1021/jm00377a016 |
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Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent Graham J. Atwell, Bruce F. Cain, Bruce C. Baguley, Graeme J. Finlay, and William A. Denny pp 1481 - 1485; DOI: 10.1021/jm00377a017 |
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Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogs Morris J. Robins, Peter W. Hatfield, Jan Balzarini, and Erik De Clercq pp 1486 - 1492; DOI: 10.1021/jm00377a018 |
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Quantitative structure-activity relationship of insect juvenile hormone mimetic compounds Akira Nakayama, Hajime Iwamura, and Toshio Fujita pp 1493 - 1502; DOI: 10.1021/jm00377a019 |
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Potentiation of the tolerogenicity of benzylpenicilloylated eicosa-L-lysine by conjugation with 4-methoxybenzyl 3.beta.-cholestanyl succinate Immanuel F. Luescher pp 1502 - 1508; DOI: 10.1021/jm00377a020 |
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Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins Willard M. Welch, Allen R. Kraska, Reinhard Sarges, and B. Kenneth Koe pp 1508 - 1515; DOI: 10.1021/jm00377a021 |
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Conformationally restricted retinoids Marcia I. Dawson, Peter D. Hobbs, Krzysztof Derdzinski, Rebecca L. S. Chan, John Gruber, Wanru Chao, Saundra Smith, Richard W. Thies, and Leonard J. Schiff pp 1516 - 1531; DOI: 10.1021/jm00377a022 |
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A theoretical investigation of histamine tautomerism Sid Topiol, Harel Weinstein, and Roman Osman pp 1531 - 1533; DOI: 10.1021/jm00377a023 |
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Book Reviews pp 1534 - 1534; DOI: 10.1021/jm00377a600 |
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2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzoxathian: a new antagonist with high potency and selectivity towards .alpha.1-adrenoreceptors Carlo Melchiorre, Livio Brasili, Dario Giardina, Maria Pigini, and Giovannella Strappaghetti pp 1535 - 1536; DOI: 10.1021/jm00378a001 |
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Cyclopentenyluridine and cyclopentenylcytidine analogs as inhibitors of uridine-cytidine kinase Mu Ill Lim, James D. Moyer, Richard L. Cysyk, and Victor E. Marquez pp 1536 - 1538; DOI: 10.1021/jm00378a002 |
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Synthesis and antifungal activity of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine (SF 86-327) and related allylamine derivatives with enhanced oral activity Anton Stuetz and Gabor Petranyi pp 1539 - 1543; DOI: 10.1021/jm00378a003 |
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Pyridonecarboxylic acids as antibacterial agents. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and its analogs Hiroshi Egawa, Teruyuki Miyamoto, Akira Minamida, Yoshiro Nishimura, Hidetsugu Okada, Hitoshi Uno, and Junichi Matsumoto pp 1543 - 1548; DOI: 10.1021/jm00378a004 |
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Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the acceptor site Donald J. Abraham, David M. Gazze, Paul E. Kennedy, and Michael Mokotoff pp 1549 - 1559; DOI: 10.1021/jm00378a005 |
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Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents Wayne K. Anderson and Allen N. Jones pp 1559 - 1565; DOI: 10.1021/jm00378a006 |
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Synthesis of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1,2,4-triazol-3-yl)thio]acetic acids as possible superoxide scavengers and antiinflammatory agents James R. Maxwell, Dan A. Wasdahl, Alan C. Wolfson, and Virgil I. Stenberg pp 1565 - 1570; DOI: 10.1021/jm00378a007 |
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Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for .mu. or .delta. opiate receptors Terrence R. Burke, Balbir S. Bajwa, Arthur E. Jacobson, Kenner C. Rice, R. A. Streaty, and W. A. Klee pp 1570 - 1574; DOI: 10.1021/jm00378a008 |
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Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones Helmut Schmidhammer, Lislott Aeppli, Louise Atwell, Florian Fritsch, Arthur E. Jacobson, Michaela Nebuchla, and Guenther Sperk pp 1575 - 1579; DOI: 10.1021/jm00378a009 |
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[[(Aminomethyl)aryl]oxy]acetic acid esters. A new class of high-ceiling diuretics. 1. Effects of nitrogen and aromatic nuclear substitution Cheuk Man Lee, Jacob J. Plattner, C. Wayne Ours, Bruce W. Horrom, Jill R. Smital, Yvonne C. Martin, Andre G. Pernet, Paul R. Bunnell, Souheir E. El Masry, and Patrick W. Dodge pp 1579 - 1587; DOI: 10.1021/jm00378a010 |
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[[(Aminomethyl)aryl]oxy]acetic acid esters. A new class of high-ceiling diuretics. 2. Modifications of the oxyacetic side chain Jacob J. Plattner, Anthony K. L. Fung, Jill R. Smital, Cheuk Man Lee, Steven R. Crowley, Andre G. Pernet, Paul R. Bunnell, Steven A. Buckner, and Lawrence T. Sennello pp 1587 - 1596; DOI: 10.1021/jm00378a011 |
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Synthesis and biological activity of new peptide segments of gastrin exhibiting gastrin antagonist property Jean Martinez, Richard Magous, Marie Francoise Lignon, Jeanine Laur, Bertrand Castro, and Jean Pierre Bali pp 1597 - 1601; DOI: 10.1021/jm00378a012 |
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A novel method of conjugation of daunomycin with antibody with a poly(L-glutamic acid) derivative as intermediate drug carrier. An anti-.alpha.-fetoprotein antibody-daunomycin conjugate Yoshinori Kato, Naoji Umemoto, Yasutaka Kayama, Hisashi Fukushima, Yumiko Takeda, Takeshi Hara, and Yutaka Tsukada pp 1602 - 1607; DOI: 10.1021/jm00378a013 |
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Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists James H. Jones, Paul S. Anderson, John J. Baldwin, Bradley V. Clineschmidt, David E. McClure, George F. Lundell, William C. Randall, Gregory E. Martin, Michael Williams, and et al. pp 1607 - 1613; DOI: 10.1021/jm00378a014 |
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Mesoionic pyridazine ribonucleosides. A novel biologically active nucleoside metabolite Ronald E. Bambury, Daniel T. Feeley, Gerald C. Lawton, John M. Weaver, and James Wemple pp 1613 - 1621; DOI: 10.1021/jm00378a015 |
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Novel pyrimidine and 1,3,5-triazine hypolipemic agents Gaetano D'Atri, Piero Gomarasca, Giuseppe Resnati, Giovanni Tronconi, Carlo Scolastico, and Cesare R. Sirtori pp 1621 - 1629; DOI: 10.1021/jm00378a016 |
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Acidic furo[3,2-b]indoles. A new series of potent antiallergy agents Paul C. Unangst, Mary E. Carethers, Kenneth Webster, Grace M. Janik, and Lillian J. Robichaud pp 1629 - 1633; DOI: 10.1021/jm00378a017 |
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Synthesis and activity of novel nitropyrazines for use as hypoxic cell radiosensitizers George D. Hartman, Richard D. Hartman, John E. Schwering, Nigel R. Jones, Peter Wardman, Margaret E. Watts, and Michael Woodcock pp 1634 - 1639; DOI: 10.1021/jm00378a018 |
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Pyrido[3',2':4,5]thieno[3,2-d]-N-triazines: a new series of orally active antiallergic agents Raymond D. Youssefyeh, Richard E. Brown, Jeffrey Wilson, Uresh Shah, Howard Jones, Bernard Loev, Atul Khandwala, Mitchell J. Leibowitz, and Paula Sonnino-Goldman pp 1639 - 1643; DOI: 10.1021/jm00378a019 |
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Effects of volume and surface property in hydrolysis by acetylcholinesterase. The trimethyl site Saul G. Cohen, Jerome L. Elkind, S. Bano Chishti, Jose L. Giner, and Heide Reese pp 1643 - 1647; DOI: 10.1021/jm00378a020 |
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Functional group contributions to drug-receptor interactions P. R. Andrews, D. J. Craik, and J. L. Martin pp 1648 - 1657; DOI: 10.1021/jm00378a021 |
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3-Substituent effect and 3-methylene substituent effect on the structure-reactivity relationship of 7.beta.-(acylamino)-3-cephem-4-carboxylic acid derivatives studied by carbon-13 and IR spectroscopy Junko Nishikawa and K. Tori pp 1657 - 1663; DOI: 10.1021/jm00378a022 |
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Peptide sweeteners. 6. Structural studies on the C-terminal amino acid of L-aspartyl dipeptide sweeteners Joseph W. Tsang, Bernhard Schmied, Rolf Nyfeler, and Murray Goodman pp 1663 - 1668; DOI: 10.1021/jm00378a023 |
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Peptide sweeteners. 7. Taste relationships of trifluoroacetyl-L-aspartylanilides Marc Rodriguez and Murray Goodman pp 1668 - 1672; DOI: 10.1021/jm00378a024 |
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A proton NMR study of the interactions and conformations of rationally designed brodimoprim analogs in complexes with Lactobacillus casei dihydrofolate reductase B. Birdsall, J. Feeney, C. Pascual, G. C. K. Roberts, I. Kompis, R. L. Then, K. Mueller, and A. Kroehn pp 1672 - 1676; DOI: 10.1021/jm00378a025 |
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A substituent constant analysis of the interaction of substituted naphthalene monoimides with DNA Karen A. Stevenson, Shau Fong Yen, Nai Chuang Yang, David W. Boykin, and W. David Wilson pp 1677 - 1682; DOI: 10.1021/jm00378a026 |
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Bulky amine analogs of ketoprofen: potent antiinflammatory agents Donald C. Schlegel, Bernard L. Zenitz, Constance A. Fellows, Stanley C. Laskowski, D. Craig Behn, Donald K. Phillips, Irving Botton, and Phyllis T. Speight pp 1682 - 1690; DOI: 10.1021/jm00378a027 |
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Azasteroids as inhibitors of rat prostatic 5.alpha.-reductase Gary H. Rasmusson, Glenn F. Reynolds, Torleif Utne, Ronald B. Jobson, Raymond L. Primka, Charles Berman, and Jerry R. Brooks pp 1690 - 1701; DOI: 10.1021/jm00378a028 |
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C(2)-Methylation abolishes DA1 dopamine agonist activity of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN): steric intolerance by the receptor David E. Nichols, James N. Jacob, Andrew J. Hoffman, Jai D. Kohli, and Dana Glock pp 1701 - 1705; DOI: 10.1021/jm00378a029 |
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N2-(4-Substituted-2,6-dichlorophenyl)-N1,N1-dimethylformamidines as antihypertensive and diuretic agents Walter E. Meyer, Andrew S. Tomcufcik, Peter S. Chan, and John E. Emma pp 1705 - 1710; DOI: 10.1021/jm00378a030 |
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A potent multisubstrate analog inhibitor of human thymidylate synthetase Ananthachari Srinivansan, Venkataraman Amarnath, Arthur D. Broom, F. C. Fou, and Yung Chi Cheng pp 1710 - 1717; DOI: 10.1021/jm00378a031 |
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Diastereomeric 6-desoxy-6-spiro-.alpha.-methylene-.gamma.-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted Michael acceptor ligand Gary A. Koolpe, Wendel L. Nelson, T. L. Gioannini, Lloyd Angel, and Eric J. Simon pp 1718 - 1723; DOI: 10.1021/jm00378a032 |
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1-Aryl-3,3-dimethyltriazenes: potential central nervous system active analogs of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) David Farquhar and John Benvenuto pp 1723 - 1727; DOI: 10.1021/jm00378a033 |
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Opioid agonists and antagonists. 6,6-Hydrazi and 6-oximino derivatives of 14-hydroxymorphinones Ronald P. Ko, Sanjeev M. Gupte, and Wendel L. Nelson pp 1727 - 1729; DOI: 10.1021/jm00378a034 |
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Synthesis and binding to tubulin of colchicine spin probes Padam N. Sharma, Arnold Brossi, J. V. Silverton, and Colin F. Chignell pp 1729 - 1733; DOI: 10.1021/jm00378a035 |
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Bis(m-nitrophenyl) and bis(p-nitrophenyl) esters and the phosphorodiamidate of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in mouse cells in culture Ram R. Chawla, Jerome J. Freed, and Alexander Hampton pp 1733 - 1736; DOI: 10.1021/jm00378a036 |
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Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine) Stewart W. Schneller, Jiann Kuan Luo, Ramachandra S. Hosmane, Erik De Clercq, Johanna D. Stoeckler, Kailash C. Agarwal, Robert E. Parks, and Priscilla P. Saunders pp 1737 - 1739; DOI: 10.1021/jm00378a037 |
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Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides Edward F. Elslager, Norman L. Colbry, John Davoll, Marland P. Hutt, Judith L. Johnson, and Leslie M. Werbel pp 1740 - 1743; DOI: 10.1021/jm00378a038 |
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Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents Magid Abou-Gharbia, Meier E. Freed, Ronald J. McCaully, Paul J. Silver, and Robert L. Wendt pp 1743 - 1746; DOI: 10.1021/jm00378a039 |
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Bis(3,5-diisopropylsalicylato)copper(II), a potent radioprotectant with superoxide dismutase mimetic activity John R. J. Sorenson pp 1747 - 1749; DOI: 10.1021/jm00378a040 |
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Synthesis and antitumor activity of tropolone derivatives. 1 Masatoshi Yamato, Kuniko Hashigaki, Nobuhiko Kokubu, Takashi Tsuruo, and Tazuko Tashiro pp 1749 - 1753; DOI: 10.1021/jm00378a041 |
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Additions and Corrections- Chloroalanyl and Propargylglycyl Dipeptides. Suicide Substrate Containing Antibacterials Kam-Sing Cheung, Steven A. Wasserman, Edward Dudek, A. Lerner, and Michael Johnston pp 1753 - 1753; DOI: 10.1021/jm00378a600 |
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Additions and Corrections-Improved Synthesis and Antitumor Evaluation of 5,8-Dideazaisofolic Acid and Closely Related Analogues J.B. Hynes, Y.C.S. Yang, J.E. McGill, S.J. Harmon, and W.L. Washtien pp 1753 - 1753; DOI: 10.1021/jm00378a601 |
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Additions and Corrections-2-Substituted Thiazolidine-4(R)-carboxylic Acids as Prodrugs of L-Cysteine. Protection of Mice Against Acetaminophen Hepatotoxicity Herbert T. Nagasawa, David J.W. Goon, William P. Muldoon, and Richard T. Zera pp 1753 - 1753; DOI: 10.1021/jm00378a602 |
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Additions and Corrections-Development of an Affinity Ligand for Purification of Adrenoceptors from Human Platelet Membranes R.M. DeMarinis, A.J. Krog, D.H. Shah, J. Lafferty, K.G. Holdenm, J.P. Hieble, W.D. Matthews, J.W. Regan, R.J. Lefkowitz, and M.G. Caron pp 1753 - 1753; DOI: 10.1021/jm00378a603 |
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Additions and Corrections-Antiextrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzo[b]thiophene Derivatives Leading to [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with Only Minimal Intrinsic Estrogenicity pp 1753 - 1753; DOI: 10.1021/jm00378a604 |
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Book Reviews pp 1754 - 1759; DOI: 10.1021/jm00378a605 |